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Adrenal adenomas are the most prevalent adrenal tumor type and are typically nonfunctional, meaning they do not produce excessive hormones ( 3.4 Adrenal steroidogenesis The pathophysiology of lethal adrenal disorders is heavily influenced by oxidative stress, and mutations in antioxidant defense genes can have a considerable impact on adrenal steroidogenesis
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Cells lacking IL-6R can still engage in signaling pathway via sIL-6R binding to GP130, termed IL-6 trans-signaling
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