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Recent studies have shown that Cu can activate HIF-1α-related pathways to stimulate the production of VEGF (Lelièvre et al., 2020), leading to tumor angiogenesis, including lung cancer (Zimna and Kurpisz, 2015
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Such death waves exhibit significant non-random spatiotemporal patterns when quantified through a computational metric called Spatial Propagation Index, or SPI [33] , and can jump over gaps of considerable distance, more than 100 microns, clearly demonstrating long-range propagative activity [13]
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