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Funding: NHLBI Division of Intramural Research to MNS (ZIA-HL005199) Abbreviations in this article: AD Alzheimer’s disease CD38 NAD + glycohydrolase (NADase) cGAS cyclic GMP-AMP synthase CTLs cytotoxic T lymphocytes EAE experimental autoimmune encephalomyelitis IDO1 indoleamine 2,3-deoxygenase 1 mtDNA mitochondrial DNA NA nicotinic acid NAM nicotinamide NAAD NA adenine dinucleotide NAMN NA mononucleotide NAD + Nicotinamide adenine dinucleotide NAMPT nicotinamide phosphoribosyltransferase NAR nicotinic acid riboside NMN nicotinamide mononucleotide NR nicotinamide riboside PARP poly(ADP-ribose) polymerase STING stimulator of interferon genes SARM sterile alpha and HEAT/Armadillo motif TCA tricarboxylic acid cycle TLR tumor infiltrating lymphocytes TLR toll-like receptors Footnotes Conflict of Interest: Dr

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However, there are some possible solutions that could help to address this issue