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Tras- tuzumab was one of the first humanized antibodies to be developed by transplanting the CDRs of the mouse human epidermal growth factor receptor 2 (HER2) antibody mumAb4D5, into a human antibody frame-work 15 , and a similar strategy was utilized to develop obinutuzumab (anti-CD20), pembrolizumab (anti-programmed cell death protein 1 (PD1)) and atezolizumab (anti-PD1 ligand 1 (PDL1)) (Table 1)