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Similarly, traditional biomarkers for pre-clinical phase of RA fail to account for lymphocyte alterations, thereby creating critical knowledge gaps in our understanding of disease progression pathways (24)

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Nitric Oxide Synthase (eNOS/iNOS) Pathway Regulation Stimulates NO production through eNOS/iNOS activation : BPC-157 upregulates nitric oxide synthesis in vascular tissue and restores endothelial homeostasis, as shown in ischemic and inflammatory models 3,4