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These proteins share a winged-helix DNA-binding domain and act as convergence points for insulin/PI3K–AKT signalling, oxidative-stress signalling and nutrient sensing

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For each of the ten novel targets, we used BoltzGen to design 60,000 nanobodies and 60,000 proteins of lengths 80-140 (lengths 80-120 for the easy targets) without specifying a binding site