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A recent meta-analysis including five studies evaluating NAC and 574 patients with depression (291 randomized to NAC and 283 to placebo) with a follow-up of 12–24 weeks revealed significantly greater improvements in depressive symptoms (MADRS) and functionality with NAC than with placebo [143]

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However, they work through different biological pathways and have different research histories, making it important to evaluate them separately

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