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Chitinase 1 (CHIT1), secreted by activated macrophages, could curb inflammatory responses, promote lipid uptake and cholesterol efflux in macrophages, and polarize macrophages towards an M2 phenotype, thus exerting protective effects against atherosclerosis [96]

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routine B12 level monitoring is generally unnecessary once replacement is established, as levels do not reliably correlate with tissue stores Important safety considerations: Older adults may have impaired renal function, though this rarely affects B12 therapy given its wide safety margin

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