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Similarly, Semax , a synthetic peptide with nootropic properties, has been shown to increase brain-derived neurotrophic factor (BDNF) and dopamine function, potentially improving cognitive flexibility and emotional regulation in individuals affected by long-term substance use (Myasoedov et al., 2013)

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The release of cortisol is characterized by both circadian and 60- to 90-minute oscillations (138)