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The feasibility of this concept was further proved by using NPs with a programmed CCM that could target the bone specifically and enhance homotypic tumor uptake ( Owing to the homologous targeting ability, CCM-NPs were commonly employed in tumor imaging and were often functionalized with more than just imaging capabilities (Rao et al., 2016
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Shown are the frequencies of CD3 + T cells, CD62L + CD45 + CD3 + CD8 + T cells, and Tcf1 + CD45 + CD3 + CD8 + T cells in NOOC1 tumor after various treatments
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