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The N-terminal metal-binding site 2 of the Wilson’s disease protein plays a key role in the transfer of copper from Atox1

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A common feature of TBI is diffuse axonal injury (DAI) (Maruta et al., 2010), which is characterized by a focal alteration of the axolemma, leading to an impairment in axonal transport and the appearance of a local swelling that then detaches from its distal segment (Povlishock and Katz, 2005)