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AMPK is a heterotrimeric complex composed of three subunits: a 63 KDa α subunit, which harbors the catalytic activity, and two regulatory subunits, β (38 kDa) and γ (38 kDa) (Willows et al

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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year