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Individuals with the ApoEε4 allele of the ApoE gene not only have a higher risk of AD in a dose-dependent manner but also tend to experience an earlier age of onset (Liu et al., 2013
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However, glutamate is a non-essential amino acid whose brain content is much greater than plasma, and studies in vivo show that glutamate does not enter the brain in appreciable quantities except in those small regions with fenestrated capillaries (circumventricular organs)
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