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Proposed mechanisms involving vascular endothelial growth factor (VEGF) and nitric oxide signaling are derived almost entirely from in vitro cell cultures and small rodent studies—such as one study involving only 12 rats with surgically ligated arteries

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By day 14, an increased amount of epithelial tissue was observed at the wound edges in both TCC and zinc oxide-treated wounds, with TCC-treated wounds also showing a small elevation of granulation tissue in the center [2]