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Size:50 ml (100 doses)

Zagami et al145 found that oxidative stress leads to early astrogliosis and impaired EAAT activity of astrocyte, pointing to a critical role of astrocytes in response to oxidative‐induced injury in an ALS model.145 In addition to its effects on glutamate uptake, ROS also affects astrocytic glutamate secretion and this might be one of the potential reasons leading to the neurotoxicity of hippocampal neurons induced by ethanol.108 Except for the influence of ROS, RNS is proved to be associated with glutamate metabolism.97 The results of some studies confirm that the both glutamate transport and metabolism in glutamate/glutamine cycle in astrocytes can be regulated by NO and NO‐induced cysteine S‐nitrosylation.97, 142 6