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The contribution of allostery to the selectivity of metal-sensor proteins (even within the same family) is highlighted by comparing this with the allosteric site of NmtR: here a six-coordinate site is required to trigger the allosteric mechanism, discriminating against Zn(II) (despite NmtR having a tight Zn(II) affinity) [100]
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doi:10.4158/EP11009.OR 63
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