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These enzymes are also inactivated by nitration of tyrosine residues (see below), indicating that they may be particularly vulnerable targets of peroxynitrite
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The research study found that curcumin treatment restored depleted GSH levels in neuronal cells, maintained mitochondrial complex I activity, activated the AKT/NRF2/HO-1 signaling pathway and prevented protein oxidation 247 (Table 3) 246 , 247
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