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FB1-induced DNA damage and hepatocarcinogenesis in experimental models can be modulated by a variety of factors including nutrients, chemopreventive agents, and other factors such as food restriction and viral infection, as well as genetic polymorphismsn rat C6 glioma cells, FB1 inhibits protein synthesis, causes DNA fragmentation and cell death, increases 8-hydroxy-2’-deoxyguanosine, induces LPO, and cell cycle arrest [119]
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Cells were allowed to migrate for 4 h at 37 °C in an atmosphere of 95% air/5% CO 2
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