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The study illustrated that Mstn expression was significantly upregulated in GASP1-overexpressing mice, which showed an increase in low oxidative muscle fibers and impaired metabolic homeostasis, but only Gdf11 but not Mstn expression was significantly elevated in GASP2-overexpressing mice, which exhibited an increase in fast glycolytic muscle fibers without metabolic defects 31
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As fat mass decreases, this conversion declines and testosterone levels normalize
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