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B-BM12 mice mouse model, with its specific point mutations in MHC class II molecules, is mainly used to artificially induce autoimmune disease models such as systemic lupus erythematosus and dry eye, as well as to study chronic transplant rejection mediated by CD4+ T cells in skin transplantation
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Consequently, this process leads to the increase in the size of fat cells and it also plays a role in the rise of blood glucose levels due to the overload on metabolism
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