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However, combinatorial strategies in subsequent studies revealed therapeutic synergy: in the Phase II CARMEN LC04 trial, dual targeting with ramucirumab (anti-VEGFR2) extended mPFS to 5.7 months, while the CARMEN-LC05 study demonstrated immune-chemotherapeutic augmentation, with Tusamitamab ravtansine + pembrolizumab or platinum doublets achieving objective response rates (ORRs) of 47.8% and 59.1%, respectively, and a pooled mPFS of 11.6 months (71, 72)

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Association was also observed with AD for ADH1C rs1614972 in a cohort of European AD patients and healthy controls [96]