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In a patient with confirmed vitamin B12 deficiency, should folic acid be given concurrently, and what are the recommended vitamin B12 and folic acid dosing regimens?
(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1α (Ero1α), leading to ER stress and subsequent inflammation
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However, many clinical trials have examined whether lowering homocysteine levels through folic acid, vitamin B12, and vitamin B6 supplementation can reduce cardiovascular disease events, typically in people with a history of cardiovascular disease
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