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If it feels like everyone is suddenly talking about peptides... you're not imagining it. One reason is a recent FDA advisory panel review of seven of the most widely discussed peptides, including

[9] Concomitant administration of large calcium supplements, thiazide diuretics, or aluminium-containing phosphate binders can potentiate vitamin D-mediated increases in serum calcium or phosphate, demanding periodic laboratory monitoring and dosage adjustments to avert nephrolithiasis or ectopic calcification

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Several residues are located in the C-terminal tail which are not resolved in the crystal structure