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Based on one study, which used immunohistochemistry to demonstrate the increased expression of HPGDS in the necrotic muscle fibers of patients with DMD and polymyositis but not in those of the small number of patients with FCMD 11 , HPGDS inhibitors have not been considered as therapeutic options in patients with FCMD

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Additionally, PCs affect glucose synthesis and metabolism by boosting the functions of enzymes including glucokinase, hexokinase, and glycogen synthase, and reducing the functions of liver enzymes like glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, and fructose-1,6-bisphosphatase (Zhang et al., 2009