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Chronic ethanol exposure activates both the intrinsic (mitochondrial) and extrinsic (death receptor-mediated) apoptotic cascades, ultimately converging on the executioner caspases-3 and -9 [44,48]
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Inonotus hispidus polypeptide also demonstrated efficacy by simultaneously rebalancing both the oral and gut microbiota, increasing health-associated genera (oral Rothia and gut Oscillospira ) while decreasing pathogenic ones, thereby relieving inflammation via the oral-gut axis (Wu et al., 2025)
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