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Moreover, in the hypothyroid animals, many of the mast cells showed partial or complete degranulation, which was in contrast to the non-activated mast cells in the animals with normal thyroid function.[ref] Other animal studies show that hypothyroidism increases mast cell infiltration into the liver and mast cell levels in the bone marrow

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Ultra-high IV doses of methyl B12 (25mg) were shown safe and potentially effective for patients with peripheral neuropathy and chronic axonal degeneration