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Ferroptosis and intrinsic drug-induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective | EurekAlert!

Next generation risk assessment (NGRA): bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling - a case study of doxorubicin with dose metrics considerations

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As a result, it is often mistaken for other conditions or dismissed as simply “feeling run down.” These symptoms can range from mild to debilitating and often include: Fatigue or extreme tiredness Brain fog or memory problems Depression and low mood Pale or jaundiced skin Numbness or tingling in hands and feet Shortness of breath or dizziness Muscle weakness A swollen, inflamed tongue (glossitis) Pins and needles (paraesthesia) Visual disturbances Heart palpitations If left untreated, vitamin B12 deficiency can lead to serious and irreversible neurological problems