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Glutathione peroxidase 4 (GPX4) as a selenoperoxidase is a key upstream regulator of ferroptosis which plays two simultaneous roles, one in converting reduced GSH to glutathione disulfide (GSSG) and the other is to inhibit ferroptosis by reducing phospholipid hydroperoxides (PLOOHs) to the corresponding alcohols (PLOHs), thereby preventing the accumulation of lipid peroxides (Yang et al., 2016)
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