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In pathological conditions, peripheral immune cells, such as T cells and neutrophils, may also infiltrate the brain and spinal cord, further intensifying the inflammation (246, 247)

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Previous studies have indeed indicated that ANGPTL7 modulates the TM’s ECM [142] and MMP-mediated ECM turnover in the TM, which leads to a reduction in outflow resistance in the conventional outflow pathway, and to maintenance of IOP homeostasis [143]