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8 Conclusions and outlook Several lines of - mainly correlative - evidence suggest that extracellular self-DNA acting as a pro-inflammatory DAMP represents a shared element that contributes to diverse life-threatening complications in patients infected with HIV-1 and with SARS-CoV 2, and that a contribution to some of the severe adverse events after vaccination with the mRNA vaccines represents a possibility that merits further investigation

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Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage