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HIF1α is required for the production of NO, IL1β and prostaglandin E2 (PGE2) as demonstrated by murine HIF1α knockout macrophages which exhibit impaired production of these key cytokines in response to Mtb infection ( Mtb infection, and this enhanced aerobic glycolysis promotes further stabilization of HIF1α ( Mtb infection in murine BMDMs, through transcriptional and protein activation of HIF1α (119)
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