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Results Engineering of IgG1 for prolonged plasma half-life By scrutinizing a human FcRn:IgG1 Fc co-crystal structure 21 , we identified three Fc amino acid residues that were substituted with the rationale to improve pH-dependent receptor binding, namely Q311R, M428E and N434W (REW) (Fig

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Consequently, the up-regulation of the brain's calcium binding proteins that were reported in this study may be the result of the lowering of Ca 2+ concentration due to the blocking of the Ca 2+ ion channel upon ingestion of mitragynine