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A similar version of this genetic modification was reported also by another lab [64] , and both papers reported that chronically high levels of circulating GDF11 were surprisingly well tolerated in mice

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The size distribution and zeta potential of the NPs were measured using a Zetasizer (Malvern Instruments Ltd, Malvern, UK) with a fixed scattering angle of 173° at 25°C, and all samples were properly dispersed in deionized (DI) water