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We hypothesized that patients with stable schizophrenia would exhibit a reduction in glutathione, glutamate, and/or glutamine in the cerebral cortex, consistent with a post-inflammatory response, and that this reduction would be most marked in patients with “residual schizophrenia”, in whom an early stage with positive psychotic symptoms has progressed to a late stage characterized by long-term negative symptoms and impairments
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Future research should employ advanced methodologies such as systems biology, single-cell transcriptomics, spatial omics, and high-resolution imaging to map the regulatory landscape of tophus formation with greater precision