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In the course of our studies, we discovered that rnp-6(G281D) developmental phenotypes were remarkably restored by feeding worms with the E

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Things Worth Discussing with Your Doctor: Baseline kidney function testing (eGFR and cystatin C) before starting B12 MTHFR genetic testing if you have a family history of kidney disease Comprehensive nutrient testing (magnesium, zinc, B6, folate) Homocysteine and methylmalonic acid baseline levels Regular urinalysis every 3-6 months if you’re on high doses Advanced urine tests if you’re high-risk Pulse dosing schedules based on your kidney function Optimal timing for taking supplements Creating Your Personal Approach Rather than following generic guidelines, it’s worth developing an individualized B12 strategy based on your kidney function, genetic factors, and how your body responds to supplementation