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Thus, 30-days application of erinacine A and S attenuated cerebral plaque loading by inhibiting plaque growth, diminishing glial cell activation, and promoting hippocampal neurogenesis in transgenic mice as Alzheimer’s disease model
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Immunohistochemical findings While HIF-1α expression was similar between the control and vitamin B12 groups, a significant up-regulation was noted in the MTX group relative to the control group
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