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Certain pathologies, like CKD, as well as aging can lead to a reduced efficiency of the body’s natural elimination pathways, therefore increasing the accumulation of these heavy metals resulting in an increase in toxicity

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Moreover, current tandem mass spectrometric sequencing speed and the semi-stochastic nature of data-dependent acquisition (DDA) make it challenging for phosphoproteomics to systematically and reproducibly analyze phosphorylation sites across large numbers of samples

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