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Interestingly, interferon-gamma (IFNγ), a cytokine that signals predominantly through the STAT1 pathway, could also up-regulate IGF-I expression but only when STAT5b was present and fully functional (Hwa et al., 2004)
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DISCUSSION In this study, we demonstrate that curcumin exerts potent effects on the angiogenic properties of microvascular endothelial cells isolated from the human intestine, inhibiting multiple stages in the angiogenic process
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