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In type 1 diabetes, where IGF-I and IGFBP-3 levels are decreased [302], substitutive rhIGF-I/IGFBP-3 therapy enhances protein [303] and glucose metabolism by controlling both endogenous glucose output and peripheral glucose uptake [304]
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Liposomal glutathione achieves higher plasma concentrations with formulation choice influenced by stability, bioavailability, and capacity to modulate systemic levels
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