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This is possibly due to overlapping anti-hyperglycemic mechanisms shared by both cagrilintide and semaglutide such as delay in gastric emptying and inhibition of postprandial glucagon secretion

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In REDEFINE 1, GI events were reported in 79.6% of CagriSema participants versus 39.9% on placebo, including nausea (55%), constipation (30.7%), and vomiting (26.1%)