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76 In recent years, the GATOR1 complex has been shown to play an important role in the pathogenesis of focal epilepsies, with DEPDC5 exhibiting a higher mutation frequency (approximately 85% of reported cases) than NPRL2 (5%) and NPRL3 (10%)

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Whereas, intravenously administered vitamin C will increase serum levels more than 100-fold: up to 30 mM (Levine 2011)