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By using a specialized 3D printer to deposit fibroblasts into specially-designed culture vessels, adding keratinocytes on top of this layer of fibroblasts, and incubating the cells in several different media formulations, the group was able to produce what they term ‘3D-bioprinted human skin equivalents’—small organoids that can be manufactured en masse and closely resemble human skin, with dermal tissue (consisting mainly of fibroblasts ) and well-stratified layers of epidermal tissue (consisting mainly of keratinocytes )