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Although histone lactylation has not yet been directly studied in PAH, given that hypoxia is a central pathological factor in PAH and that significant lactate accumulation and M2 macrophage polarization are observed in PAH patients, histone lactylation may contribute to PAH pathogenesis through these mechanisms, promoting pulmonary vascular remodeling and disease progression

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(2011) Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis