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A 2013 randomized double-blind placebo-controlled trial by Griese and colleagues in the American Journal of Respiratory and Critical Care Medicine randomized 153 cystic fibrosis patients (73 glutathione, 80 placebo) to inhaled glutathione 646 mg via eFlow nebulizer every 12 hours versus placebo for 6 months and found no statistically significant benefit on the primary FEV1 endpoint (pre-post difference p = 0.180